References

Books ## (look for used copies or go to university library)

Molecular Biology of the Cell (If you can only purchase one book, get this one.) https://www.ncbi.nlm.nih.gov/books/NBK21054/

DNA Methylation and Complex Human Disease (Translational Epigenetics) https://www.elsevier.com/books/dna-methylation-and-complex-human-disease/neidhart/978-0-12-420194-1

Ankylosing Spondylitis In Clinical Practice https://www.springer.com/us/book/9780857291790

Ankylosing Spondylitis and the Spondyloarthropathies https://www.sciencedirect.com/book/9780323031042/ankylosing-spondylitis-and-the-spondyloarthropathies

Ankylosing Spondylitis and Klebsiella https://www.springer.com/us/book/9781447142997

Ankylosing Spondylitis https://global.oup.com/academic/product/ankylosing-spondylitis-9780195368079

Rheumatoid Arthritis https://global.oup.com/academic/product/rheumatoid-arthritis-9780199754212

General

Spondyloarthritis: new insights into clinical aspects, translational immunology and therapeutics. http://insights.ovid.com/pubmed?pmid=29889692

Metabolic syndrome, autoimmunity and rheumatic diseases. https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(17)31334-8

Genetics of immune-mediated inflammatory diseases. https://doi.org/10.1111/cei.13101

Fatigue in ankylosing spondylitis is associated with the brain networks of sensory salience and attention. https://doi.org/10.1002/art.38244

Periodontal Disease as a Risk Factor for Rheumatoid Arthritis: A Systematic Review. https://www.ncbi.nlm.nih.gov/pubmed/27820156

HLA-B27

The ramifications of HLA-B27 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079257/pdf/0970010.pdf

Role of HLA-B27 in the pathogenesis of ankylosing spondylitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364987/pdf/mmr-15-04-1943.pdf

HLA-B27 Misfolding and Ankylosing Spondylitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857088/pdf/nihms525885.pdf

HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488392/pdf/pone.0130811.pdf

An update on the genetics of HLA-B27 associated acute anterior uveitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083239/pdf/nihms-289702.pdf

Immune function in ankylosing spondylitis: apparent relationship between streptococcal responses and HLA B27 https://www.ncbi.nlm.nih.gov/pubmed/325206

HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis. https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(18)30589-4

Intestinal flora

Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27863183/

Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997922/pdf/CRR-11-47.pdf

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(15)00517-3

Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall–King Hypothesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895656/pdf/fmed-05-00080.pdf

Gut Microbiome of the Canadian Arctic Inuit https://msphere.asm.org/content/2/1/e00297-16.full-text.pdf

The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates. https://linkinghub.elsevier.com/retrieve/pii/S0165-2478(17)30570-9

Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(17)31607-8

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=28069576

Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals. https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(17)30011-2

Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26838600/

Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29967798/

These few are regarding livestock...not humans, but they are interesting none-the-less

High-grain diets altered rumen fermentation and epithelial bacterial community and resulted in rumen epithelial injuries of goats. https://dx.doi.org/10.1007/s00253-017-8427-x

Diet-induced inflammation: From gut to metabolic organs and the consequences for the health and longevity of ruminants. https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(18)30465-X

Gut/Brain axis (not all links here are specific to AS, but important info)

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27090302/

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26046241/

Influence of gut microbiota on neuropsychiatric disorders. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28852308/

The Role of Microbiota in Depression - a brief review. http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol30_no2/dnb_vol30_no2_136.pdf

Neurotransmitter modulation by the gut microbiota. https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(18)30150-1

Gastrointestinal hormones and the dialogue between gut and brain. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24566540/

Crosstalk Between Gut Microbiota and the Central Nervous System: A Focus for Alzheimer's Disease. http://www.eurekaselect.com/165118/article

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer's disease. https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(17)31475-5

Making Sense of… the Microbiome in Psychiatry. https://academic.oup.com/ijnp/article-lookup/doi/10.1093/ijnp/pyy067

The gut microbiota: A new target in the management of alcohol dependence? https://linkinghub.elsevier.com/retrieve/pii/S0741-8329(18)30046-6

Centrally Acting Agents for Obesity: Past, Present, and Future. https://dx.doi.org/10.1007/s40265-018-0946-y

Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29615850/

permeability

Increased intestinal permeability in ankylosing spondylitis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379462/pdf/gut00575-0156a.pdf

Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. https://www.researchgate.net/publication/19130347_Abnormal_bowel_permeability_in_ankylosing_spondylitis_and_Rheumatoid_Arthritis

Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379244/pdf/gut00593-0052.pdf

Bowel permeability and CD45RO expression on circulating CD20+ B cells in patients with ankylosing spondylitis and their relatives. https://www.researchgate.net/publication/13371404_Bowel_permeability_and_CD45RO_expression_on_circulating_CD20_B_cells_in_patients_with_ankylosing_spondylitis_and_their_relatives

Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28123927/

Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29401627/

Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16456012

Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. http://www.tandfonline.com/doi/full/10.1080/00365520500235334

immune system biochemistry

Immune cells involved in the pathogenesis of ankylosing spondylitis. https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)35933-4

Role of innate immune system in the pathogenesis of ankylosing spondylitis. https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(18)32586-1

Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29670461/

Lymphocyte transformation to connective tissue antigens in adult and juvenile rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic lupus erythematosus, and a nonarthritic control population https://linkinghub.elsevier.com/retrieve/pii/0008-8749(83)90153-3

Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30208882/

Th1 and Th2 responses: what are they? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/pdf/424.pdf

Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29984038/

Functional Defects of Treg Cells: New Targets in Rheumatic Diseases, Including Ankylosing Spondylitis. https://dx.doi.org/10.1007/s11926-018-0729-1

High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26634249/

Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30132545/

Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26065006/

Regulation of Osteoclast Differentiation by Cytokine Networks https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29503739/

Treatments

Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450150/pdf/12891_2017_Article_1600.pdf

Comparison of the effect of treatment with Nonsteroidal anti-inflammatory drugs added to anti-tumour necrosis factor a therapy versus anti-tumour necrosis factor a therapy alone on progression of Structural damage in the spine over two years in patients with ankyLosing spondylitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623356/pdf/bmjopen-2016-014591.pdf

New treatment paradigms in spondyloarthritis. http://insights.ovid.com/pubmed?pmid=28984648

Cannabinoids as novel anti-inflammatory drugs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/pdf/nihms155268.pdf

Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model. https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(13)00734-5

because it's a neat read

Ankylosing spondylitis in the pharaohs of ancient Egypt. https://dx.doi.org/10.1007/s00296-002-0242-7

View the RAW markdown.